eISSN: 2391-6052
ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Suplementy Zeszyty specjalne Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
2/2024
vol. 11
 
Poleć ten artykuł:
Udostępnij:
streszczenie artykułu:
Artykuł oryginalny

Relationship between the switched memory B level and clinical course of coronavirus disease 2019 in patients with common variable immunodeficiency

Filiz Sadi Aykan
1
,
Fatih Çölkesen
1
,
Eray Yıldız
2
,
Mehmet Kılınç
1
,
Recep Evcen
1
,
Şevket Arslan
1

  1. Department of Allergy and Clinical Immunology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
  2. Department of Allergy and Clinical Immunology, Necip Fazıl City Hospital, Kahramanmaraş, Turkey
Alergologia Polska – Polish Journal of Allergology 2024; 11, 2: 148–153
Data publikacji online: 2024/06/07
Pełna treść artykułu Pobierz cytowanie
 
Metryki PlumX:


Introduction:
Among the primary immunodeficiency spectrum, the most common symptomatic type is common variable immunodeficiency (CVID).

Aim:
This study aims to investigate the relationship of class-switched memory B cells (cSMBCs) (CD19+CD27+IgD) with the clinical course of coronavirus disease-2019 (COVID-19) in patients with CVID.

Material and methods:
This single-centre retrospective study evaluated the clinical features, serum immunoglobulin (Ig) levels, and cSMBC levels of 24 polymerase chain reaction (PCR)-confirmed patients with CVID and COVID-19. The COVID-19 disease severity classification, mortality rate, hospitalisation, symptoms, and PCR positivity durations of the patients were recorded.

Results:
The median age of CVID patients included in the study was 48 (32–58), and 15 of them (62.5%) were female. Disease was severe in 8 (33%) patients, 3 (12.5%) of whom were followed in the intensive care unit and died. The serum IgA, IgM, and CD19+ B lymphocyte cell levels were similar between the mild-moderate and severe disease groups. The cSMBC level was significantly lower in the severe disease group (p = 0.01). The hospitalisation, COVID-19 symptom, and PCR positivity durations were significantly longer in the group with a low cSMBC level (p < 0.05). The cSMBC level was negatively correlated with PCR positivity duration (r = 0.397, p = 0.038).

Conclusions:
The cSMBC level is related to the clinical course of COVID-19 in patients with CVID. The cSMBC levels has prognostic value in patients with COVID-19.




© 2024 Termedia Sp. z o.o.
Developed by Bentus.